Effect of different high alumina cements on the properties of self flow castable with distribution coefficient 0.21.

The aim of this project is to study the effect of varying concentration of binding phase on the properties of high alumina self flow castable with distribution coefficient q fixed at 0.21 according to dinger-funk’s continuous particle size distribution model. The binders used were CA-14 cement and polycem-75 cement. The XRD analysis of the two types of cement binder used is done. The varying binder concentration used in the four batches were 4% CA-14 cement, 4% polycem-75 cement,6% CA-14 cement and 6% polycem 75 cement respectively .The batches are prepared according to the conventional processing techniques and water is added till the self flowable characteristics is obtained .The batches were then dried at 1100C for 36 hours and fired at 10000C and 16000C . The final products were then characterized for bulk density, volume shrinkage and cold crushing strength

Preparation and evaluation of mucoadhesive microspheres of repaglinide for treatment of diabetes mellitus type II

Type 2 diabetes mellitus (T2DM) is the most common form of diabetes constituting 90% of the diabetic population. The number of patients with diabetes in India is currently around 40.9 million and is expected to rise to 101 million by 2030.Majority of the conventional formulations available have some drawbacks and less bioavailability, to overcome their deficiency an attempt was made to formulate mucoadhesive of Repaglinide for the treatment of Diabetes mellitus type II ,Prepared formulations were subjected for different evaluation parameters like Particle Size Analysis, Production Yield, Bulk Density, Tapped Density and Compressibility Index, Swelling Index, Mucoadhesivity study, Entrapment efficiency, Differential Scanning calorimeter and in vitro drug release study. Best formulation was chosen who passed all the evaluation parameters

Preparation and evaluation of mucoadhasive microspheres of Propranolol HCl for nasal delivery

In the recent decades, the interest in intranasal route for drug delivery is increased as the nasal mucosa offers numerous benefits such as rapid systemic drug absorption and fast onset of action. Additionally, intranasal absorption avoids the hepatic presystemic metabolism and enhances drug bioavailability in comparison to that obtained after oral administration. Also, it offers patient ease being non invasive, offers favourable tolerability profile and it is also pharmaceutically economic as dont require sterilization. Propranolol HCl is the most commonly used ? blocker drug for the prophylaxis of migraine. The problem with the oral route is low bioavailability (26%) due to pre-systemic metabolism. So, the aim of the work is to formulate and evaluate mucoadhesive microsphere of Propranolol HCl to increase its bioavailability and reduce its dose. Mucoadhesive microspheres increase the residence time of the drug by gel formation mechanism and hence improve bioavailability as compared to powder and liquid formulations. The prepared formulation was evaluated for particle size, shape and morphology, mucoadhesive strength, micrometric properties, in vitro drug diffusion study, entrapment efficiency and stability studies

Formulation and Evaluation of Modified release Bilayer Tablet of Paracetamol and Diclofenac sodium

The main objective of this research work is to develop a stable formulation of a NASAID drugs an immediate release layer of Paracetamol and sustain release layer of Diclofenac sodium are combine to the bilayer and evaluate their pre-compression and post-compression parameters A bilayer tablet comprises first layer formulated for instant release of the paracetamol from a dissolving tablet and a second layer formulated for sustain release Diclofenac sodium from a bilayer tablet The formulation was initiated with preparing granules of both the drug individually by wet granulation method and then then they were compressed to prepare bilayer tablet. The compressed bilayer tablets were evaluated for weight variation, thickness, hardness, friability, in-vitro drug release using USP dissolution apparatus and interaction study by DSC. The optimized Formulation table of formulations F5 formulation was found to be acceptable because it release drug up to 82.11 % of drug release for bilayer Tablet and this batch passed all the evaluation parameters

Lockdown and Insomnia among Undergraduate Healthcare Students: A Cross-Sectional Study

INTRODUCTION: Insomnia is a risk factor for various physical and mental disorders as well can affect the academic performance of a student(s). AIM: To assess the prevalence of insomnia among university going students (medical, dental and nursing streams) in the South Asian continent during the lockdown due to the COVID-19 pandemicMATERIALS AND METHOD: The present study was conducted amongst 743 medical, dental and nursing undergraduate students residing in South Asia using convenience sampling. Data was collected using a pre-tested and pre-validated questionnaire [the Athens Insomnia Scale (AIS)] using google forms and had a total of 8 questions (score range 0-3) . Final scores (the individual AIS score) were obtained by adding the scores for each question (range 0 -24). The higher the score was, the worse was the sleep quality; students with score of ≥ 6 were considered insomniac. Data Analysis was done using SPSS version 21.012 by using the independent samples t-test, and multiple logistic regression.RESULTS: A total of 921 entries were recorded, out of which 743 were complete and hence, were included in the study (response rate: 80.7%). Insomnia was reported in 421 (56.7%) students, out of which, the highest was seen among dental (62.7%), followed by medical (59.8%) and nursing (45.3%) undergraduates. The highest range of AIS was observed among females (6-22) and dental students (6-21). Gender differences revealed a significant association among females in both range obtained (t-test) (p=0.03) as well as the multiple linear regression analyzing insomnia in relation to gender (p=0.03).CONCLUSION: There is a need to regularly assess insomnia among students and to take preventive measures incase of high prevalence is found among them, especially while pursuing academics online and from their homes due to the pandemic

Observation of multiple attractors and diffusive transport in a periodically driven Klein-Gordon chain

We consider a Klein-Gordon chain that is periodically driven at one end and has dissipation at one or both boundaries. An interesting numerical observation in a recent study~[arXiv:2209.03977] was that for driving frequency in the phonon band, there is a range of values of the driving amplitude $F_d\in (F_1, F_2)$ over which the energy current remains constant. In this range, the system exhibits a "resonant nonlinear wave" (RNW) mode of energy transmission which is a time and space periodic solution. It was noted that the range $(F_1,F_2)$, for which the RNW mode occurs, shrinks with increasing system size $N$ and disappears eventually. Remarkably, we find that the RNW mode is in fact a stable solution even for $F_d$ much larger than $F_2$ and quite large $N$ ($\approx 1000$). For $F_d>F_{2}$, there exists a second attractor which is chaotic. Both attractors have finite basins of attraction and can be reached by appropriate choice of initial conditions. Corresponding to the two attractors for large $F_d$, the system can now be in two nonequilibrium steady states. We improve the perturbative treatment of [arXiv:2209.03977] for the RNW mode by including the contributions of the third harmonics. We also consider the effect of thermal noise at the boundaries and find that the RNW mode is stable for small temperatures. Finally, we present results for a different driving protocol studied in [arXiv:2205.03839] where $F_d$ is taken to scale with system size as $N^{-1/2}$ and there is dissipation only at the non-driven end. We find that the steady state can be characterized by Fourier's law as in [arXiv:2205.03839] for a stochastic model. We point out interesting differences that occur since our dynamics is nonlinear and Hamiltonian. Our results suggest the intriguing possibility of observing the high current carrying RNW phase in experiments by careful preparation of initial conditions.Comment: 11 pages, 14 figure

RELEVANCE OF KAKOLI (ONE AMONG ASTAVARGA) IN ANCIENT AYURVEDIC TREATISE ALONG WITH ETYMOLOGY OF ITS VARIOUS SANSKRIT SYNONYMS

The knowledge about medicinally useful plants in the early age is scientifically documented, and systematically organized in Ayurveda Samhitas, Nighantus and other texts. The ancient nomenclature of Ayurvedic herbs was not only useful for their identification but also to know their medicinal values for example, Payasvinī means galactogogue, Kākolī means which contains high moisture value, Madhurā means Madhura in Rasa, etc. Moreover, our Acharyas also suggested different names of the Ayurvedic herbs based on their habits, taxonomy and uses. Though the modern science is successful in classifying the flora taxonomically, but could not reach up to the ground breaking concept of classifying plants according to their medicinal properties. Being aware of taxonomic aspects of nomenclature along with the torch of synonyms coined by ancient seers one may be able to preserve the treasury traditional medicinal knowledge. Kākolī has been mentioned as one of the Aṣṭavarga plants. Kākolī has also been documented in the various Saṁhitā and Nighaṇṭu. Description of Kākolī along with its Sanskrit synonyms, habitat and medicinal properties has also been mentioned in different Nighaṇṭu. However, due to the lack of appropriate taxonomic data, mainly three plant species i.e., Roscoea purpurea Sm., Roscoea capitata Sm. and Roscoea alpina Royle are widely accepted as Kākolī. The main objective of this study was to critically review the Sanskrita name of Kākolī described in classical Ayurvedic literature along with medicinal properties